Description
JNJ-38877605 is a potent, selective, ATP-competitive inhibitor of catalytic activity c-Met with IC50 of 4nM; exhibits >600-fold selectivity (cFMS IC50=2.6uM; the next potently inhibited kinase) against a panel of 250 diverse tyrosine and serine-threonine kinases; inhibits Met phosphorylation associated with dose-dependent tumor growth inhibition in tumor xenograft models; orally bioavailable. Solid Tumors Phase 1 Discontinued